Drug Metabolism and Pharmacokinetics | SRI International
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Drug Metabolism and Pharmacokinetics

SRI offers comprehensive drug metabolism and pharmacokinetic (DMPK) services to meet your needs. We give you access to a complete range of capabilities, beginning with dose administration followed by full-service bioanalytical support and pharmacokinetic data analysis and interpretation. We offer PK studies that fully comply with U.S. FDA GLP regulations.

Related Services

Bioanalytical Quantitative Methods

  • Bioanalytical method development and validation

    • Small molecules: LC/MS/MS, GC-MS, HPLC with UV,
      fluorescence, radiochemical detection

    • Proteins: ELISA, antibody titer

  • Quantitative PCR

    • DNA/RNA test article, e.g., plasmid, virus

    • Biodistribution, persistence, integration

    • mRNA expression levels

    • Subcellular localization

    • Chromosomal integration

Pharmacokinetic and Pharmacodynamic

  • Single-dose pharmacokinetics

  • Bioavailability

  • Multiple-dose pharmacokinetics

  • Drug accumulation

  • Metabolite identification

  • WinNonlin™ compartmental and noncompartmental analysis

  • PK/PD interpretation

  • Bioequivalence

  • Allometric estimations

  • Formulation screening

Comprehensive ADME

  • Absorption and clearance

  • Tissue distribution

  • DNA/RNA biodistribution, persistence, integration

  • Interspecies comparative metabolism

  • Metabolite profile

  • Excretion and mass balance

  • Radiolabeled drug synthesis



Innovative Science Overcomes Formulation Challenges

Innovative Science Overcomes Formulation Challenges

Partnering to Advance Therapy for Radiation Exposure

Partnering to Advance Therapy for Radiation Exposure

SRI researcher working with lab equipment

Metabolite Standards Synthesis Center

SRI is enabling and improving metabolomics research with high-quality reference standards.

nicotine molecule with cigarettes

DMET Genes, Nicotine Metabolism, and Prospective Abstinence

Researchers are seeking to identify novel genes contributing to nicotine metabolism and to smoking cessation.